ABSTRACT
Calcifying cystic odontogenic tumor (CCOT) are uncommon benign slow-growing cysts of developmental origin partly exhibiting characteristics of a neoplasm. Until date, the exact behavior of CCOT had been enigmatic and still the lesion portrays a platform to be debatable. The lesion has been reviewed and readdressed from the date first reported about its diverse clinical and histopathological features. The name of the lesion itself has undergone extensive review for the same reason. We report a case of calcifying odontogenic cyst in the mandible with a review of the literature. This paper also highlights the update on nomenclature and classification.
Subject(s)
Asymptomatic Diseases , Female , Humans , Mandible/pathology , Middle Aged , Odontogenic Cyst, Calcifying/classification , Odontogenic Cyst, Calcifying/diagnosis , Odontogenic Cyst, Calcifying/pathology , Odontogenic Cyst, Calcifying/diagnostic imaging , Odontogenic Cyst, Calcifying/surgery , Review Literature as TopicABSTRACT
Plasma cells are medium-sized round-to-oval cells with eccentrically placed nuclei, usually found in the red pulp of the spleen, tonsils, medulla of the lymph nodes, nasal mucosa, upper airway, lamina propria of the gastrointestinal tract, and sites of inflammation. Plasma cell granuloma is a rare reactive tumor-like proliferation composed chiefly of plasmacytic infiltrate. Here, we present a case of plasma cell granuloma of lip in a female patient.
Subject(s)
Biopsy , Diagnosis, Differential , Female , Granuloma, Plasma Cell/diagnosis , Humans , Lip Diseases/diagnosis , Middle Aged , Oral Ulcer/diagnosis , Plasma Cells/pathology , Stomatitis/diagnosisABSTRACT
Aim: The aim of this study is to evaluate oral submucous fibrosis (OSMF) by clinical and histopathological examination, and compare the results with those from ultrasonographic technique. Materials and Methods: 30 clinically diagnosed OSMF patients were subjected to both ultrasonographic and histopathological evaluation before treatment. Later, only ultrasonographical examination was done during 4 th and 8 th week of treatment. Prognosis of the lesion for the treatment was evaluated. Peak systolic velocity (PSV) of blood in the lesional area was statistically analyzed. 10 normal individuals without any mucosal lesions were considered as the control group. Results: In normal individuals, ultrasonography delineates normal mucosa with uniform fine mottled appearance with interspersed hypoechoic areas. Color Doppler and spectral Doppler depicts uniform distribution of blood vessels and normal peak systolic velocity of blood respectively. All OSMF patients were diagnosed upon clinical and histopathological examination. Clinical examination revealed 14 individuals with unilateral palpable fibrotic bands and 16 individuals with bilateral fibrotic bands whereas, ultrasonographic evaluation revealed 6 individuals with unilateral fibrotic bands and 24 individuals were with bilateral fibrotic bands, which was statistically significant. Ultrasonography demonstrated number, length and thickness of the fibrotic bands. Color Doppler and spectral Doppler showed decreased vascularity and PSV in lesional area. Prognosis evaluation revealed 25 cases of good prognosis and 5 cases were showed poor prognosis. Wilcoxon Signed Ranks Test revealed no significant difference of PSV was seen in poor prognosis patients. Conclusion: Ultrasonography is a non-invasive diagnostic tool for OSMF. It could be a better diagnostic tool compared to clinical and histopathological examination.
Subject(s)
Adult , Blood Flow Velocity/physiology , Blood Vessels/diagnostic imaging , Dexamethasone/administration & dosage , Dexamethasone/analogs & derivatives , Dexamethasone/therapeutic use , Drug Combinations , Fibrosis , Follow-Up Studies , Glucocorticoids/administration & dosage , Glucocorticoids/therapeutic use , Humans , Hyaluronoglucosaminidase/administration & dosage , Hyaluronoglucosaminidase/therapeutic use , Injections, Intralesional , Mouth Mucosa/blood supply , Oral Submucous Fibrosis/drug therapy , Oral Submucous Fibrosis/pathology , Oral Submucous Fibrosis/diagnostic imaging , Prognosis , Pulsatile Flow/physiology , Treatment Outcome , Ultrasonography, Doppler , Ultrasonography, Doppler, Color , Ultrasonography, Doppler, Duplex , Young AdultABSTRACT
Introduction: Oral submucous fibrosis (OSMF) is a chronic, progressive, scarring disease that predominantly affects the people of south-east Asian origin. Aim: The present study is aimed at comparing and correlating the mast cell density (MCD) and micro vascular density (MVD) in normal mucosa and different grades of OSMF and to analyze their role in the disease progression. Materials and Methods: MCD was assessed immunohistochemically using anti mast cell tryptase and MVD was assessed using anti-factor VIII related von Willebrand factor. Results: The one way comparison of MVD and MCD in normal mucosa and among different grades of OSMF showed a significant increase in MCD and MVD among OSMF cases. Correlation analysis using Pearson correlation coefficient, showed positive correlation between MCD and MVD i.e. as MCD increases there is an exponential increase in MVD. Conclusion: The increase in MVD and MCD reveals their role in the pathogenesis of OSMF, a lesion characterized by progressive fibrosis in early stages and failure of degradation or remodeling in the advanced stages.